AustralieFrV1, Main, Exploration, bibRecord, 006779

R1507, a Monoclonal Antibody to the Insulin-Like Growth Factor 1 Receptor, in Patients With Recurrent or Refractory Ewing Sarcoma Family of Tumors: Results of a Phase II Sarcoma Alliance for Research Through Collaboration Study

Identifieur interne : 006779 ( Main/Exploration ); précédent : 006778; suivant : 006780

R1507, a Monoclonal Antibody to the Insulin-Like Growth Factor 1 Receptor, in Patients With Recurrent or Refractory Ewing Sarcoma Family of Tumors: Results of a Phase II Sarcoma Alliance for Research Through Collaboration Study

Auteurs : Alberto S. Pappo [États-Unis] ; Shreyaskumar R. Patel [États-Unis] ; John Crowley [États-Unis] ; Denise K. Reinke [États-Unis] ; Klaus-Peter Kuenkele [Allemagne] ; Sant P. Chawla [États-Unis] ; Guy C. Toner [Australie] ; Robert G. Maki [États-Unis] ; Paul A. Meyers [États-Unis] ; Rashmi Chugh [États-Unis] ; Kristen N. Ganjoo [États-Unis] ; Scott M. Schuetze [États-Unis] ; Heribert Juergens [Allemagne] ; Michael G. Leahy [Royaume-Uni] ; Birgit Geoerger [France] ; Robert S. Benjamin [États-Unis] ; Lee J. Helman [États-Unis] ; Laurence H. Baker [États-Unis]

Source :

Journal of clinical oncology [ 0732-183X ] ; 2011.

RBID : Pascal:12-0030471

Descripteurs français

Pascal (Inist)
- Facteur croissance IGF1, Anticorps monoclonal, Récepteur biologique, Sarcome d'Ewing, Homme, Récidive, Essai clinique phase II, Résistance traitement, Recherche, Cancérologie.
Wicri :
- topic : Homme, Recherche.

English descriptors

KwdEn :
- Biological receptor, Cancerology, Ewing sarcoma, Human, Insulin like growth factor 1, Monoclonal antibody, Phase II trial, Relapse, Research, Treatment resistance.

Abstract

Purpose The type 1 insulin-like growth factor 1 receptor (IGF-1 R) has been implicated in the pathogenesis of the Ewing sarcoma family of tumors (ESFT). We conducted a multicenter phase II study of the fully human IGF-1R monoclonal antibody R1507 in patients with recurrent or refractory ESFT. Patients and Methods Patients ≥ 2 years of age with refractory or recurrent ESFT received R1507 at doses of 9 mg/kg intravenously one a week or 27 mg/kg intravenously every three weeks. Response was measured by using WHO criteria. Tumor imaging was performed every 6 weeks for 24 weeks and then every 12 weeks. Results From December 2007 through April 2010, 115 eligible patients from 31 different institutions were enrolled. The median age was 25 years (range, 8 to 78 years). The location of the primary tumor was bone in 57% of patients and extraskeletal in 43% of patients. A total of 109 patients were treated with R1507 9 mg/kg/wk, and six patients were treated with 27 mg/kg/3 wk. The overall complete response/partial response rate was 10% (95% CI, 4.9% to 16.5%). The median duration of response was 29 weeks (range, 12 to 94 weeks), and the median overall survival was 7.6 months (95% CI, 6 to 9.7 months). Ten of 11 responses were observed in patients who presented with primary bone tumors (P = .016). The most common adverse events of grades 3 to 4 were pain (15%), anemia (8%), thrombocytopenia (7%), and asthenia (5%). Conclusion R1507 was a well-tolerated agent that had meaningful and durable benefit in a subgroup of patients with ESFT. The identification of markers that are predictive of a benefit is necessary to fully capitalize on this approach.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236654

Affiliations:

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">R1507, a Monoclonal Antibody to the Insulin-Like Growth Factor 1 Receptor, in Patients With Recurrent or Refractory Ewing Sarcoma Family of Tumors: Results of a Phase II Sarcoma Alliance for Research Through Collaboration Study</title>
<author><name sortKey="Pappo, Alberto S" sort="Pappo, Alberto S" uniqKey="Pappo A" first="Alberto S." last="Pappo">Alberto S. Pappo</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>St Jude Children's Research Hospital</s1>
<s2>Memphis, TN</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
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<author><name sortKey="Patel, Shreyaskumar R" sort="Patel, Shreyaskumar R" uniqKey="Patel S" first="Shreyaskumar R." last="Patel">Shreyaskumar R. Patel</name>
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<wicri:noRegion>MD Anderson Cancer Center</wicri:noRegion>
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<author><name sortKey="Crowley, John" sort="Crowley, John" uniqKey="Crowley J" first="John" last="Crowley">John Crowley</name>
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<author><name sortKey="Kuenkele, Klaus Peter" sort="Kuenkele, Klaus Peter" uniqKey="Kuenkele K" first="Klaus-Peter" last="Kuenkele">Klaus-Peter Kuenkele</name>
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<author><name sortKey="Toner, Guy C" sort="Toner, Guy C" uniqKey="Toner G" first="Guy C." last="Toner">Guy C. Toner</name>
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<author><name sortKey="Chugh, Rashmi" sort="Chugh, Rashmi" uniqKey="Chugh R" first="Rashmi" last="Chugh">Rashmi Chugh</name>
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<author><name sortKey="Ganjoo, Kristen N" sort="Ganjoo, Kristen N" uniqKey="Ganjoo K" first="Kristen N." last="Ganjoo">Kristen N. Ganjoo</name>
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</affiliation>
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<author><name sortKey="Schuetze, Scott M" sort="Schuetze, Scott M" uniqKey="Schuetze S" first="Scott M." last="Schuetze">Scott M. Schuetze</name>
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<s2>Ann Arbor, MI</s2>
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</author>
<author><name sortKey="Juergens, Heribert" sort="Juergens, Heribert" uniqKey="Juergens H" first="Heribert" last="Juergens">Heribert Juergens</name>
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<country>Allemagne</country>
<wicri:noRegion>Muenster</wicri:noRegion>
<wicri:noRegion>University Children's Hospital</wicri:noRegion>
<wicri:noRegion>University Children's Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Leahy, Michael G" sort="Leahy, Michael G" uniqKey="Leahy M" first="Michael G." last="Leahy">Michael G. Leahy</name>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Christie Hospital National Health Service Foundation Trust</s1>
<s2>Manchester</s2>
<s3>GBR</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Geoerger, Birgit" sort="Geoerger, Birgit" uniqKey="Geoerger B" first="Birgit" last="Geoerger">Birgit Geoerger</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Institut Gustave Roussy</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
<wicri:noRegion>Institut Gustave Roussy</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Benjamin, Robert S" sort="Benjamin, Robert S" uniqKey="Benjamin R" first="Robert S." last="Benjamin">Robert S. Benjamin</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MD Anderson Cancer Center</s1>
<s2>Houston, TX</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>MD Anderson Cancer Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Helman, Lee J" sort="Helman, Lee J" uniqKey="Helman L" first="Lee J." last="Helman">Lee J. Helman</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>National Cancer Institute</s1>
<s2>Bethesda, MD</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>National Cancer Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baker, Laurence H" sort="Baker, Laurence H" uniqKey="Baker L" first="Laurence H." last="Baker">Laurence H. Baker</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>University of Michigan</s1>
<s2>Ann Arbor, MI</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>University of Michigan</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of clinical oncology</title>
<title level="j" type="abbreviated">J. clin. oncol.</title>
<idno type="ISSN">0732-183X</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of clinical oncology</title>
<title level="j" type="abbreviated">J. clin. oncol.</title>
<idno type="ISSN">0732-183X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biological receptor</term>
<term>Cancerology</term>
<term>Ewing sarcoma</term>
<term>Human</term>
<term>Insulin like growth factor 1</term>
<term>Monoclonal antibody</term>
<term>Phase II trial</term>
<term>Relapse</term>
<term>Research</term>
<term>Treatment resistance</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Facteur croissance IGF1</term>
<term>Anticorps monoclonal</term>
<term>Récepteur biologique</term>
<term>Sarcome d'Ewing</term>
<term>Homme</term>
<term>Récidive</term>
<term>Essai clinique phase II</term>
<term>Résistance traitement</term>
<term>Recherche</term>
<term>Cancérologie</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
<term>Recherche</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Purpose The type 1 insulin-like growth factor 1 receptor (IGF-1 R) has been implicated in the pathogenesis of the Ewing sarcoma family of tumors (ESFT). We conducted a multicenter phase II study of the fully human IGF-1R monoclonal antibody R1507 in patients with recurrent or refractory ESFT. Patients and Methods Patients ≥ 2 years of age with refractory or recurrent ESFT received R1507 at doses of 9 mg/kg intravenously one a week or 27 mg/kg intravenously every three weeks. Response was measured by using WHO criteria. Tumor imaging was performed every 6 weeks for 24 weeks and then every 12 weeks. Results From December 2007 through April 2010, 115 eligible patients from 31 different institutions were enrolled. The median age was 25 years (range, 8 to 78 years). The location of the primary tumor was bone in 57% of patients and extraskeletal in 43% of patients. A total of 109 patients were treated with R1507 9 mg/kg/wk, and six patients were treated with 27 mg/kg/3 wk. The overall complete response/partial response rate was 10% (95% CI, 4.9% to 16.5%). The median duration of response was 29 weeks (range, 12 to 94 weeks), and the median overall survival was 7.6 months (95% CI, 6 to 9.7 months). Ten of 11 responses were observed in patients who presented with primary bone tumors (P = .016). The most common adverse events of grades 3 to 4 were pain (15%), anemia (8%), thrombocytopenia (7%), and asthenia (5%). Conclusion R1507 was a well-tolerated agent that had meaningful and durable benefit in a subgroup of patients with ESFT. The identification of markers that are predictive of a benefit is necessary to fully capitalize on this approach.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>France</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Grand Manchester</li>
</region>
<settlement><li>Manchester</li>
</settlement>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Pappo, Alberto S" sort="Pappo, Alberto S" uniqKey="Pappo A" first="Alberto S." last="Pappo">Alberto S. Pappo</name>
</noRegion>
<name sortKey="Baker, Laurence H" sort="Baker, Laurence H" uniqKey="Baker L" first="Laurence H." last="Baker">Laurence H. Baker</name>
<name sortKey="Benjamin, Robert S" sort="Benjamin, Robert S" uniqKey="Benjamin R" first="Robert S." last="Benjamin">Robert S. Benjamin</name>
<name sortKey="Chawla, Sant P" sort="Chawla, Sant P" uniqKey="Chawla S" first="Sant P." last="Chawla">Sant P. Chawla</name>
<name sortKey="Chugh, Rashmi" sort="Chugh, Rashmi" uniqKey="Chugh R" first="Rashmi" last="Chugh">Rashmi Chugh</name>
<name sortKey="Crowley, John" sort="Crowley, John" uniqKey="Crowley J" first="John" last="Crowley">John Crowley</name>
<name sortKey="Ganjoo, Kristen N" sort="Ganjoo, Kristen N" uniqKey="Ganjoo K" first="Kristen N." last="Ganjoo">Kristen N. Ganjoo</name>
<name sortKey="Helman, Lee J" sort="Helman, Lee J" uniqKey="Helman L" first="Lee J." last="Helman">Lee J. Helman</name>
<name sortKey="Maki, Robert G" sort="Maki, Robert G" uniqKey="Maki R" first="Robert G." last="Maki">Robert G. Maki</name>
<name sortKey="Meyers, Paul A" sort="Meyers, Paul A" uniqKey="Meyers P" first="Paul A." last="Meyers">Paul A. Meyers</name>
<name sortKey="Patel, Shreyaskumar R" sort="Patel, Shreyaskumar R" uniqKey="Patel S" first="Shreyaskumar R." last="Patel">Shreyaskumar R. Patel</name>
<name sortKey="Reinke, Denise K" sort="Reinke, Denise K" uniqKey="Reinke D" first="Denise K." last="Reinke">Denise K. Reinke</name>
<name sortKey="Schuetze, Scott M" sort="Schuetze, Scott M" uniqKey="Schuetze S" first="Scott M." last="Schuetze">Scott M. Schuetze</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Kuenkele, Klaus Peter" sort="Kuenkele, Klaus Peter" uniqKey="Kuenkele K" first="Klaus-Peter" last="Kuenkele">Klaus-Peter Kuenkele</name>
</noRegion>
<name sortKey="Juergens, Heribert" sort="Juergens, Heribert" uniqKey="Juergens H" first="Heribert" last="Juergens">Heribert Juergens</name>
</country>
<country name="Australie"><noRegion><name sortKey="Toner, Guy C" sort="Toner, Guy C" uniqKey="Toner G" first="Guy C." last="Toner">Guy C. Toner</name>
</noRegion>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Leahy, Michael G" sort="Leahy, Michael G" uniqKey="Leahy M" first="Michael G." last="Leahy">Michael G. Leahy</name>
</region>
</country>
<country name="France"><noRegion><name sortKey="Geoerger, Birgit" sort="Geoerger, Birgit" uniqKey="Geoerger B" first="Birgit" last="Geoerger">Birgit Geoerger</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur les relations entre la France et l'Australie

R1507, a Monoclonal Antibody to the Insulin-Like Growth Factor 1 Receptor, in Patients With Recurrent or Refractory Ewing Sarcoma Family of Tumors: Results of a Phase II Sarcoma Alliance for Research Through Collaboration Study

R1507, a Monoclonal Antibody to the Insulin-Like Growth Factor 1 Receptor, in Patients With Recurrent or Refractory Ewing Sarcoma Family of Tumors: Results of a Phase II Sarcoma Alliance for Research Through Collaboration Study

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